Editorial: Autoinflammatory Keratinization Disease (AiKD)

Behçet’s Disease: Autoimmune or Autoinflammatory?

Behçet's disease (BD) is a systemic inflammatory disease characterized by recurrent oral aphthae, genital ulcers, ocular inflammation and skin lesions. Involvement of large vessels, central nervous system, and gastrointestinal tract, and thrombotic events are less frequent but can be life threatening. Ocular complications of BD are some of the most devastating for patients with a major impact o...

Autoinflammatory Disease Reloaded: A Clinical Perspective

Our understanding of the etiology of autoinflammatory disease is growing rapidly. Recent advances offer new opportunities for therapeutic intervention and suggest that the definition of what constitutes an autoinflammatory disease should be reassessed.

Is Still's Disease an Autoinflammatory Syndrome?

Systemic juvenile idiopathic arthritis (sJIA), formerly called Still's disease, is officially classified as a subset of juvenile idiopathic arthritis (JIA). Beside arthritis, it is characterized by prominent systemic features and a marked inflammatory response. Even if it is still included in the group of juvenile arthritides, sJIA is set apart from all the other forms of JIA. This disorder has...

Keratinization and its disorders.

Keratins are a diverse group of structural proteins that form the intermediate filament network responsible for maintaining the structural integrity of keratinocytes. In humans, there are around 30 keratin families divided into two groups, namely, acidic and basic keratins, which are arranged in pairs. They are expressed in a highly specific pattern related to the epithelial type and stage of c...

Editorial: “Disease-Only” alleles and genotypes in complex disorders?